Table 3.
Comparison of cognitive performance between the pravastatin group and the placebo group
Pravastatin | Placebo | |||||||||||||||
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Baseline (N=30) | Six weeks (N=28) | Twelve weeks (N=24) | Baseline (N=30) | Six weeks (N=26) | Twelve weeks (N=25) | |||||||||||
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Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | t | p* | t | p* | |
Attention/vigilance | 32.12 | 12.66 | 35.25 | 12.47 | 34.04 | 11.69 | 37.33 | 12.77 | 37.72 | 13.92 | 38.04 | 15.19 | 0.79 | 0.43 | −0.26 | 0.8 |
Working memory | 32.04 | 16.41 | 33.62 | 16.4 | 35.79 | 14.6 | 34.4 | 12.59 | 36.56 | 11.86 | 35.8 | 11.51 | −0.46 | 0.65 | 1.11 | 0.27 |
Verbal Learning | 37.04 | 11.46 | 39.91 | 12.24 | 41.41 | 13.71 | 38.76 | 12.47 | 38.2 | 9.81 | 43.24 | 11.57 | 1.69 | 0.1 | −0.14 | 0.89 |
Visual Learning | 35.5 | 15.26 | 37.16 | 15.42 | 38.33 | 19.13 | 33.48 | 11.71 | 35.16 | 13.96 | 37.68 | 10.86 | 0.21 | 0.83 | −0.3 | 0.76 |
Problem solving | 39.87 | 9.25 | 42.41 | 9.35 | 42.45 | 11.03 | 42.6 | 9.02 | 44.84 | 9.69 | 46.16 | 11.17 | −0.17 | 0.87 | −0.57 | 0.57 |
Social cognition | 36.95 | 9.41 | 37.08 | 13.86 | 36 | 11.64 | 34.96 | 15.08 | 35.6 | 15.13 | 35.76 | 13.68 | −0.17 | 0.86 | −0.6 | 0.55 |
MATRICS composite Score | 25.33 | 16.98 | 28.87 | 18.79 | 29.37 | 18.09 | 28.75 | 12.31 | 29.8 | 13.44 | 32.04 | 13.11 | 0.72 | 0.47 | −0.11 | 0.91 |
P-values obtained from ANCOVA models using change scores as the dependent variable, and baseline score and treatment group as covariates