Fig. 1.
Comparison between experimental and modeling results of the thermodynamics and kinetics for the four protein pairs shows good qualitative agreement. (A) Experimentally determined difference in stabilities between WT and des proteins (data and experimental details from refs. 17, 21). (B) chevron plots comparison of the refolding and unfolding kinetics. (C) Comparison of computed heat capacity (Cv) profiles. (D) Comparison of computed folding and unfolding kinetics. Data for the WT proteins and des variants are shown as black circles–lines and red squares–lines, respectively. See Materials and Methods for experimental and computational details. Protein identity is indicated in each plot.