Stereotypy after stress. (A) Minimum and maximum A06 viral spread in dorsolateral striatum (DLS). (B) Reduced density ChAT-positive interneurons in the DLS in DLS-targeted mice after DT treatment, relative to C06-infected controls; see also Figs. S2 and S3. Student’s t test: t(9) = 4.8, P = 0.001. (C) Elevated fragmented/stereotypic grooming after startle stress in DLS ChAT-ablated mice. RM-ANOVA: main effect of block, F(2,18) = 4.85, P = 0.042; main effect of group, F(1,9) = 9.63, P = 0.013; group × block interaction, F(2,18) = 4.26, P = 0.055). (D) Viral spread in dorsomedial striatum (DMS)-targeted mice. (E) Reduced ChAT-positive interneurons, quantified over the entire striatum, in DMS-targeted mice after DT treatment, relative to C06-infected controls. Student’s t test: t(11) = 5.9, P < 0.001. (F) Normal grooming behavior after startle stress in DMS ChAT-ablated mice. RM-ANOVA: main effect of block, F(2,22) = 14, P = 0.004; main effect of group, F(1,11) = 0.034, P > 0.5; block × group interaction, F(2,22) = 0.20, P > 0.5).