Table 2.

Main endogenous and exogenous factors to be considered as inclusion/exclusion criteria for Phase II trials on sarcopenia.

Endogenous	Exogenous
Age	Physical activity level
Gender	Smoking status
Race/Ethnicity	Nutritional status
Inflammation	Alcohol consumption
Hormonal modifications	Medications use
Baseline body composition	Social support*
Clinical conditions (e.g., AIDS, anemia, arthritis, cancer, chronic obstructive pulmonary disease, cognitive impairment*, congestive heart failure, depression diabetes, kidney disease, metabolic syndrome, neurological diseases [stroke, spinal compression], Parkinson's disease)

^*These factors do not directly influence the study outcomes (i.e., muscle decline), but may significantly affect the conduction of the study