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. 2015 Jan 30;10(1):e0115351. doi: 10.1371/journal.pone.0115351

Fig 10. Internalized PrPres is trafficked to late endosomes/lysosomes.

Fig 10

Neuron-enriched or non-neuronal cultures containing cells with internalized 263KA647 (B, F, J, M and Q) were incubated with the following markers: DextranA488 for 5 minutes (A) as a marker for early endosomes or 16 h (E) as a marker for late endosomes/lysosomes; AcLDL (I) as a late endosomal/lysosomal marker in fibroblasts; Ctx (L) as a marker for rafts; and LysoTracker (P) as a marker for acidic organelles. Arrows indicate areas of co-localization. Arrowheads indicate areas without co-localization.