Table 3. Sibling pair analysis of the associations of one standard deviation increase in peak weight and height velocity the first 36 months of life with development of respiratory disorders.
| Outcome | Number of discordant sibling pairs in analysis | Exposure | Crude OR (95% CI) | Adj OR (95% CI) a | Adj OR (95% CI) b |
|---|---|---|---|---|---|
| Current asthma at 36 months | 488 | Peak weight velocity | 1.36 (1.15, 1.60) | 1.27 (1.04, 1.55) | 1.26 (1.03, 1.55) |
| Peak height velocity | 1.14 (0.99, 1.32) | 0.96 (0.80, 1.15) | 0.96 (0.80, 1.15) | ||
| Recurrent LRTIs by 36 months | 370 | Peak weight velocity | 1.06 (0.88, 1.27) | 0.93 (0.75, 1.17) | 0.94 (0.75, 1.19) |
| Peak height velocity | 0.92 (0.78, 1.08) | 0.81 (0.66, 0.98) | 0.81 (0.66, 0.98) | ||
| Current asthma at 7 years | 127 | Peak weight velocity | 1.24 (0.92, 1.68) | 1.03 (0.68, 1.55) | 1.01 (0.66, 1.54) |
| Peak height velocity | 1.26 (0.97, 1.62) | 1.19 (0.82, 1.72) | 1.21 (0.83, 1.76) |
LRTIs- lower respiratory tract infections
aAdjusted for maternal age, maternal parity, maternal education, maternal salary, maternal height, maternal pre-pregnancy BMI, paternal height, paternal BMI, maternal folate intake during pregnancy, maternal smoking during pregnancy, maternal asthma, paternal asthma, child gender, gestational age and breast feeding the first 6 months of life.
bAdditional adjustment for the child’s BMI at 36 months (current asthma at 36 months and recurrent LRTIs by 36 months) or 7 years (current asthma at 7 years).
Multiple imputation of missing covariate information conducted using chained equations. A total of 20 imputed datasets generated for pooled analysis.