Table 4. Summary of non-parametric linkage results in twelve multiply affected disease pedigrees.
| Family ID | Minimum observed linkage p genome-wide | Power (p < 0.01, see Methods) | Size (Mb) of linkage region at p < 0.01 | Number of rare, LoF and non-synonymous variants in linkage region |
|---|---|---|---|---|
| DA | 0.005 | 0.22 | 25.47 | 6 |
| BRK | 0.0011 | 0.24 | 40.08 | 3 |
| BRE | 0.0004 | 0.02 | 23.76 | 1 |
| HMN | 0.005 | 0.41 | 71.63 | 3 |
| BD | 0.05 | 0 | 0 | 0 |
| BR | 0.004 | 0.17 | 46.04 | 0 |
| BUT | 0.003 | 0.43 | 34.34 | 0 |
| SDY | 0.03 | 0.75 | 0 | 0 |
| FAM008 | 0.0002 | 0.22 | 29.01 | 0 |
| FAM063 | 0.0008 | 0.84 | 52.42 | 2 |
| FAM014 | 0.005 | 0.75 | 26.98 | 3 |
| H | 0.05 | 0 | 0 | 0 |
Summary of linkage data for the twelve families included in the NPL analysis. The linkage p-values were computed using Merlin [33]. The power was assessed using simulations (see Methods).