Table 2. Expression of mutidrug resistance-related genes in the series of MCF-7/ADR-n cell lines.
MCF-7 / WT | ADR-1 | ADR-2 | ADR-4 | ADR-8 | ADR-16 | ADR-32 | ADR-64 | ADR-128 | ADR-256 | ADR-512 | ADR-1024 | MCF-7/ ADR | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MDR-1 | 1.0 | 0.8 | 0.9 | 0.7 | 0.7 | 0.9 | 1.3 | 1.8 | 1.7 | 1.1 | 1.4 | 8.3 | 6.6 |
MRP-1 | 1.0 | 0.8 | 0.9 | 1.1 | 1.9 | 1.2 | 1.9 | 3.7 | 6.8 | 6.3 | 1.8 | 1.4 | 1.7 |
Bcl-2 | 1.0 | 0.8 | 0.8 | 1.0 | 0.9 | 0.8 | 0.7 | 0.5 | 0.8 | 0.8 | 0.7 | 0.1 | 0.2 |
Bid | 1.0 | 0.7 | 0.7 | 0.7 | 0.7 | 0.8 | 0.7 | 0.7 | 0.9 | 0.7 | 0.8 | 0.7 | 0.6 |
Bax | 1.0 | 0.7 | 0.6 | 0.7 | 0.7 | 0.8 | 0.6 | 0.7 | 0.7 | 0.7 | 0.6 | 0.8 | 1.1 |
c-FLIP | 1.0 | 0.7 | 0.7 | 0.7 | 0.7 | 0.8 | 0.7 | 0.8 | 0.8 | 0.8 | 0.9 | 1.1 | 1.1 |
GCS | 1.0 | 1.2 | 1.3 | 1.2 | 1.5 | 1.9 | 2.2 | 2.1 | 2.5 | 1.9 | 2.3 | 1.9 | 1.9 |
BRCA-1 | 1.0 | 2.0 | 2.0 | 2.8 | 2.5 | 2.2 | 1.1 | 1.5 | 0.8 | 0.2 | 0.2 | 0.3 | 0.3 |
BRCA-2 | 1.0 | 1.8 | 1.8 | 2.9 | 2.6 | 1.8 | 0.6 | 1.1 | 0.4 | 0.2 | 0.3 | 0.2 | 0.2 |
wild type p53 | 1.0 | 0.9 | 0.8 | 0.5 | 0.7 | 1.1 | 1.2 | 1.1 | 1.1 | 1.1 | 0.5 | 0.1 | 0.1 |
mutant p53 | 1.0 | 1.2 | 1.3 | 1.7 | 1.9 | 2.0 | 2.2 | 1.9 | 2.3 | 2.4 | 2.5 | 4.9 | 7.1 |
Nrf-2 | 1.0 | 0.8 | 0.9 | 1.2 | 1.1 | 1.0 | 0.9 | 0.7 | 0.5 | 0.8 | 0.5 | 0.5 | 1.1 |
Keap-1 | 1.0 | 1.1 | 1.1 | 1.0 | 1.3 | 1.3 | 1.6 | 1.3 | 1.2 | 1.1 | 1.2 | 1.5 | 1.5 |
γγ-GCL | 1.0 | 0.9 | 0.9 | 0.9 | 0.9 | 0.8 | 0.9 | 0.8 | 0.7 | 0.8 | 0.8 | 0.5 | 0.7 |
HO-1 | 1.0 | 0.9 | 0.9 | 0.8 | 0.8 | 0.8 | 1.1 | 1.0 | 1.0 | 0.9 | 1.2 | 0.7 | 0.8 |
HIF-1-αα | 1.0 | 0.7 | 0.7 | 0.5 | 0.5 | 0.5 | 0.7 | 0.7 | 0.6 | 0.5 | 0.5 | 0.6 | 0.9 |
GR | 1.0 | 0.9 | 0.9 | 0.9 | 1.2 | 1.3 | 1.4 | 1.3 | 1.4 | 1.3 | 1.7 | 1.4 | 2.2 |
GST-ππ | 1.0 | 0.6 | 0.5 | 0.4 | 0.4 | 0.4 | 0.6 | 0.4 | 0.4 | 0.3 | 0.4 | 6.7 | 7.7 |
PKC-αα | 1.0 | 1.1 | 1.6 | 1.1 | 1.1 | 1.5 | 1.9 | 3.1 | 1.7 | 1.6 | 2.0 | 4.2 | 6.1 |
E-cadherin | 1.0 | 1.0 | 0.8 | 0.9 | 1.0 | 0.8 | 0.6 | 0.8 | 0.6 | 0.9 | 0.8 | 0.2 | 0.2 |
N-cadherin | 1.0 | 0.9 | 0.8 | 0.9 | 1.5 | 1.6 | 0.8 | 0.8 | 0.7 | 1.0 | 0.8 | 4.8 | 16.6 |
Snail | 1.0 | 1.8 | 1.5 | 2.2 | 1.9 | 1.7 | 0.8 | 0.9 | 0.6 | 1.2 | 0.6 | 1.4 | 0.8 |
ZEB-1 | 1.0 | 0.7 | 1.0 | 0.9 | 1.2 | 1.4 | 1.1 | 2.1 | 0.6 | 0.5 | 0.5 | 2.6 | 4.0 |
ZEB-2 | 1.0 | 1.4 | 1.3 | 1.1 | 1.3 | 1.1 | 1.2 | 1.0 | 1.0 | 1.1 | 0.9 | 3.4 | 6.0 |
Twist | 1.0 | 1.2 | 1.0 | 1.2 | 1.2 | 1.1 | 1.1 | 1.0 | 1.1 | 1.1 | 1.1 | 7.2 | 6.3 |
Slug | 1.0 | 0.5 | 0.5 | 0.8 | 0.6 | 0.6 | 0.5 | 0.7 | 0.6 | 0.7 | 1.3 | 8.0 | 11.5 |
VIM | 1.0 | 1.0 | 0.6 | 1.3 | 1.6 | 1.0 | 0.5 | 0.8 | 0.5 | 0.6 | 0.6 | 4.3 | 5.2 |
Relative mRNA levels are showned as indicated when the expression in MCF-7/WT is regarded as 1.0. The MCF-7/ADR-n cell lines are presented as the abbreviated ADR-n in this table.