Table 2. Expression of mutidrug resistance-related genes in the series of MCF-7/ADR-n cell lines.

	MCF-7 / WT	ADR-1	ADR-2	ADR-4	ADR-8	ADR-16	ADR-32	ADR-64	ADR-128	ADR-256	ADR-512	ADR-1024	MCF-7/ ADR
MDR-1	1.0	0.8	0.9	0.7	0.7	0.9	1.3	1.8	1.7	1.1	1.4	8.3	6.6
MRP-1	1.0	0.8	0.9	1.1	1.9	1.2	1.9	3.7	6.8	6.3	1.8	1.4	1.7
Bcl-2	1.0	0.8	0.8	1.0	0.9	0.8	0.7	0.5	0.8	0.8	0.7	0.1	0.2
Bid	1.0	0.7	0.7	0.7	0.7	0.8	0.7	0.7	0.9	0.7	0.8	0.7	0.6
Bax	1.0	0.7	0.6	0.7	0.7	0.8	0.6	0.7	0.7	0.7	0.6	0.8	1.1
c-FLIP	1.0	0.7	0.7	0.7	0.7	0.8	0.7	0.8	0.8	0.8	0.9	1.1	1.1
GCS	1.0	1.2	1.3	1.2	1.5	1.9	2.2	2.1	2.5	1.9	2.3	1.9	1.9
BRCA-1	1.0	2.0	2.0	2.8	2.5	2.2	1.1	1.5	0.8	0.2	0.2	0.3	0.3
BRCA-2	1.0	1.8	1.8	2.9	2.6	1.8	0.6	1.1	0.4	0.2	0.3	0.2	0.2
wild type p53	1.0	0.9	0.8	0.5	0.7	1.1	1.2	1.1	1.1	1.1	0.5	0.1	0.1
mutant p53	1.0	1.2	1.3	1.7	1.9	2.0	2.2	1.9	2.3	2.4	2.5	4.9	7.1
Nrf-2	1.0	0.8	0.9	1.2	1.1	1.0	0.9	0.7	0.5	0.8	0.5	0.5	1.1
Keap-1	1.0	1.1	1.1	1.0	1.3	1.3	1.6	1.3	1.2	1.1	1.2	1.5	1.5
γγ-GCL	1.0	0.9	0.9	0.9	0.9	0.8	0.9	0.8	0.7	0.8	0.8	0.5	0.7
HO-1	1.0	0.9	0.9	0.8	0.8	0.8	1.1	1.0	1.0	0.9	1.2	0.7	0.8
HIF-1-αα	1.0	0.7	0.7	0.5	0.5	0.5	0.7	0.7	0.6	0.5	0.5	0.6	0.9
GR	1.0	0.9	0.9	0.9	1.2	1.3	1.4	1.3	1.4	1.3	1.7	1.4	2.2
GST-ππ	1.0	0.6	0.5	0.4	0.4	0.4	0.6	0.4	0.4	0.3	0.4	6.7	7.7
PKC-αα	1.0	1.1	1.6	1.1	1.1	1.5	1.9	3.1	1.7	1.6	2.0	4.2	6.1
E-cadherin	1.0	1.0	0.8	0.9	1.0	0.8	0.6	0.8	0.6	0.9	0.8	0.2	0.2
N-cadherin	1.0	0.9	0.8	0.9	1.5	1.6	0.8	0.8	0.7	1.0	0.8	4.8	16.6
Snail	1.0	1.8	1.5	2.2	1.9	1.7	0.8	0.9	0.6	1.2	0.6	1.4	0.8
ZEB-1	1.0	0.7	1.0	0.9	1.2	1.4	1.1	2.1	0.6	0.5	0.5	2.6	4.0
ZEB-2	1.0	1.4	1.3	1.1	1.3	1.1	1.2	1.0	1.0	1.1	0.9	3.4	6.0
Twist	1.0	1.2	1.0	1.2	1.2	1.1	1.1	1.0	1.1	1.1	1.1	7.2	6.3
Slug	1.0	0.5	0.5	0.8	0.6	0.6	0.5	0.7	0.6	0.7	1.3	8.0	11.5
VIM	1.0	1.0	0.6	1.3	1.6	1.0	0.5	0.8	0.5	0.6	0.6	4.3	5.2

Relative mRNA levels are showned as indicated when the expression in MCF-7/WT is regarded as 1.0. The MCF-7/ADR-n cell lines are presented as the abbreviated ADR-n in this table.