Figure 6.

Copy number loss and downregulation of NDUFB6 are associated with poor prognosis by analyzing TCGA dataset. (A) NDUFB6 DNA copy number correlates with its mRNA expression. In 405 cases of ccRCC obtained from the TCGA dataset, NDUFB6 DNA copy number correlated with its mRNA expression level (Pearson correlation coefficient = 0.4113, P < 0.0001). The x-axis displays the NDUFB6 DNA copy number (log₂). The y-axis displays the NDUFB6 expression fold change (log₂). (B) Lower NDUFB6 DNA copy number and mRNA expression level are associated with poor prognosis. (a) Recurrence-free survival rates (shown by Kaplan–Meier curve) for 83 cases obtained from TCGA dataset who showed NDUFB6 DNA copy number less than −0.25 (log₂), were lower than those for 322 cases who showed more than −0.25 (log₂) (P = 0.0005 determined by log-rank test). (b) Recurrence-free survival rates (shown by Kaplan–Meier curve) for 47 cases obtained from TCGA dataset who showed NDUFB6 expression fold change less than −1.0 (log₂) were lower than those for 29 cases who showed more than 1.0 (log₂) (P = 0.0191 determined by log-rank test).