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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: J Pharm Sci. 2015 Jan 11;104(2):627–639. doi: 10.1002/jps.24295

Figure 7.

Figure 7

Extent of DNI deamidation as measured by cIEF increased during storage at higher temperatures and in the presence of aluminum hydroxide adjuvant when stored as liquid formulations. Lyophilized DNI vaccines showed no increase in deamidation events during storage, even at higher temperatures. DNI samples include: liquid formulation at 4 °C (black) and 40 °C (blue), liquid aluminum formulation at 4 °C (red) and 40 °C (pink), lyophilized formulation at 40 °C (green), and lyophilized aluminum formulation at 40 °C (navy). Representative cIEF electropherograms are shown in Supplemental Figure S1. See methods section for calculation of deamidation events; duplicate samples were analyzed in triplicate (n=6) with error bars showing standard deviation values.