Table 1.

Characteristics of male lysosomal acid lipase-deficient mice at weaning and in early adulthood

Parameters	Average age (days)
	21±0.1		93±1
LAL genotype	+/+	−/−	+/+	−/−
SOAT2 genotype	+/+	+/+	+/+	+/+
Body weight (g)	10.5±1.5	11.6±0.4	30.1±0.5	28.9±0.8
Liver weight (g)	0.53±0.09	0.77±0.04	1.33±0.02	4.82±0.18*
Relative liver weight (% bw)	5.0±0.1	6.6±0.2*	4.4±0.1	16.8±1.0*
Small intestine weight (g)	0.42±0.05	0.62±0.02*	1.02±0.04	1.31±0.10
Hepatic esterified cholesterol concentration (mg/g)	1.6±0.4	28.4±0.4*	0.4±0.04	45.8±2.8*
Hepatic unesterified cholesterol concentration (mg/g)	2.2±0.1	2.3±0.2	2.0±0.03	5.1±0.2*
Whole-liver cholesterol content (mg/organ)	1.9±0.1	24.7±0.7*	3.2±0.1	255.6±9.2*
Small intestine esterified cholesterol concentration (mg/g)	0.16±0.02	1.34±0.05*	nm	nm
Small intestine unesterified cholesterol concentration (mg/g)	3.0±0.1	2.6±0.1	nm	nm
Whole-small intestine cholesterol content (mg/organ)	1.3±0.1	2.5±0.1*	2.6±0.1	8.8±0.4*
Plasma ALT activity (units/L)	34±3	48±9	37±1	759±152*

All mice were weaned at 21 days of age and thereafter were fed ad libitum a basal rodent chow diet.

They were studied in a fed state.

Values are mean ± 1 SEM of data from 5–7 mice per group.

^*p<0.05 compared to corresponding Lal^+/+:Soat2^+/+ mice of the same age.

nm-not measured