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. Author manuscript; available in PMC: 2015 Jul 29.
Published in final edited form as: Nature. 2014 Nov 17;517(7536):626–630. doi: 10.1038/nature13910

Figure 4. Calcitonin and RAMP3 receptors are required for secreted IAPP to suppress tumorigenesis.

Figure 4

Cartoon depicting treatment of cells expressing the indicated siRNAs and treated with media from the cells secreting IAPP on the left (a). Extracellular acidification rate (ECAR) in H1299 cells (b). Immunofluorescence (IF) for ROS (c) and apoptosis (d). MRI and quantification of thymic lymphomas treated with placebo (e, h, & k), pramlintide (f, i, & l), or pramlintide plus calcitonin inhibitor (CalR I) (g, j, & m), n=5 mice. Cartoon of IAPP signaling through RAMP3 and calcitonin receptor (CALCR) to inhibit glycolysis and induce ROS and apoptosis (n). Kaplan Meier curves from patients with p53 mutant tumours and co-expression of IAPP, RAMP3 and CALCR (o). Boxed numbers represent median survival.