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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: J Pharm Sci. 2014 Nov 21;104(2):602–611. doi: 10.1002/jps.24259

Figure 2.

Figure 2

Time lapse images of mAb1 solution in a fully filled vial as it contacts a solid surface after being dropped from a height of 40 inches. In the third frame, recorded 330 microseconds after contact, many large bubbles appear and grow until they begin to collapse in the seventh frame labeled 990 microseconds. These cavitation bubbles collapse rapidly, with complete collapse occurring around 1300 microseconds after the initial contact. The Teflon® bumper on which the vials were mounted in the mechanical shock tester is visible in the bottom of each frame.