VDR affects patterns of Paneth cells in VDRΔIEC mice. (A) Representative images showed patterns of Paneth cells. D0, normal (yellow circle); D1, disordered (green circle); D2, depleted (yellow circle); D3, diffuse (yellow circle). (B) Representative images of indirect immunofluorescence of sections stained for lysozyme (red) in ileal crypts of VDRΔIEC and VDRloxP/loxP mice. (C) Percentage of Paneth cells displayed normal and abnormal (D1 to D3) patterns of lysozyme expression (n=10/group, * P<0.05). (D) Decreased lysozyme (lyz) in VDRΔIEC mice (n=3/group, * P<0.05).