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Western blots show the effect of Smac 066 on caspases in extracts from human fibroblast-like synoviocytes (FLS) derived from patients with rheumatoid arthritis (RA). Levels of cleaved caspase 8 (a) and cleaved caspase 3 (b) were measured in RA-FLS untreated (ctrl) or treated with Smac 060, Smac 066, or with the apoptosis inducer staurosporine (stauro). Cells were incubated for 6 h with 15 μM staurosporine as a positive control.
