Table 3.
Sensitivity and Specificity of First-Degree Relatives' Reports of Any Cancer, Female Breast Cancer, and Ovarian Cancer by Kinship Type, New York Breast Cancer Family Registry, 2007–2013
| Cancer Site and Type of First-Degree Relative | No. of True-Positive Reports | No. of False-Positive Reports | No. of False-Negative Reports | No. of True-Negative Reports | Sensitivity, % | 95% CI | Specificity, % | 95% CI |
|---|---|---|---|---|---|---|---|---|
| Any Cancer | ||||||||
| Parents | 279 | 49 | 21 | 215 | 93.0 | 89.5, 95.6 | 81.4a,b | 76.2, 85.9 |
| Siblings | 498 | 91 | 58 | 866 | 89.6 | 86.7, 92.0 | 90.5 | 88.5, 92.3 |
| Offspring | 129 | 23 | 11 | 383 | 92.1 | 86.4, 96.0 | 94.3 | 91.6, 96.4 |
| Female Breast Cancer | ||||||||
| Parents | 190 | 11 | 12 | 203 | 94.1 | 89.9, 96.9 | 94.9 | 91.0, 97.4 |
| Siblings | 396 | 47 | 25 | 777 | 94.1 | 91.4, 96.1 | 94.3 | 92.5, 95.8 |
| Offspring | 108 | 17 | 8 | 321 | 93.1 | 86.9, 97.0 | 95.0 | 92.1, 97.0 |
| Ovarian Cancer | ||||||||
| Parents | 17 | 2 | 1 | 396 | 94.4 | 72.7, 99.9 | 99.5 | 98.2, 99.9 |
| Siblings | 33 | 7 | 7 | 1,198 | 82.5 | 67.2, 92.7 | 99.4 | 98.8, 99.8 |
| Offspring | 7 | 1 | 1 | 445 | 87.5 | 47.4, 99.7 | 99.8 | 98.7, 99.9 |
Abbreviation: CI, confidence interval.
a
P < 0.05 (Bonferroni-adjusted P value for comparison with siblings).
b
P < 0.05 (Bonferroni-adjusted P value for comparison with offspring).