Table 1.
Physiological variables
| Evans-Blue Study | FITC-dexran Study | |||||||
|---|---|---|---|---|---|---|---|---|
| Saline - 6 h | DHA - 6 h | Saline - 24 h | DHA - 24 h | Saline - 72 h | DHA - 72 h | Saline - 72 h | DHA - 72 h | |
| (n=9) | (n=9) | (n=9) | (n=8) | (n=12) | (n=12) | (n=7) | (n=6) | |
| Before MCAo (15min) | ||||||||
| Cranial Temperature (°C) | 37.2 ± 0.1 | 37.4 ± 0.1 | 37.1 ± 0.1 | 37.1 ± 0.2 | 37.4 ± 0.1 | 37.2 ± 0.1 | 37.2 ± 0.2 | 37.2 ± 0.2 |
| Rectal Temperature (°C) | 37.2 ± 0.1 | 37.3 ± 0.1 | 37.2 ± 0.1 | 37.3 ± 0.2 | 37.3 ± 0.1 | 37.2 ± 0.1 | 37.0 ± 0.1 | 37.0 ± 0.2 |
| pH | 7.49 ± 0.0 | 7.53 ± 0.0 | 7.50 ± 0.1 | 7.47 ± 0.0 | 7.47 ± 0.0 | 7.53 ± 0.0 | 7.4 ± 0.1 | 7.5 ± 0.0 |
| pO2 (mmHg) | 113.3 ± 4.1 | 120.7 ± 4.6 | 113.8 ± 6.8 | 114.9 ± 5.0 | 119.8 ± 3.7 | 120.4 ± 4.2 | 126.3 ± 8.5 | 113.7 ± 0.7 |
| pCO2 (mmHg) | 39.3 ± 0.4 | 38.7 ± 0.7 | 40.1 ± 0.6 | 38.4 ± 0.8 | 39.0 ± 0.5 | 38.1 ± 0.6 | 39.1 ± 0.9 | 38.3 ± 5.1 |
| Plasma Glucose (mg/dL) | 167.1 ± 12.7 | 171.2 ± 8.8 | 166.3 ± 9.9 | 194.9 ± 12.7 | 171.1 ± 13.0 | 161.7 ± 8.0 | 196.9 ± 6.1 | 204.7 ± 13.2 |
| Hematocrit (%) | 45.7 ± 12.7 | 45.8 ± 0.9 | 44.4 ± 0.8 | 45.8 ± 0.5 | 57.2 ± 11.7 | 45.8 ± 0.6 | 45.6 ± 0.6 | 45.8 ± 1.0 |
| During MCAo (15 min) | ||||||||
| Cranial Temprature (°C) | 37.6 ± 0.1 | 37.6 ± 0.1 | 37.4 ± 0.1 | 37.3 ± 0.1 | 37.7 ± 0.1 | 37.2 ± 0.1 | 37.6 ± 0.2 | 37.6 ± 0.1 |
| Rectal Temperature (°C) | 37.6 ± 0.1 | 37.4 ± 0.1 | 37.5 ± 0.1 | 37.5 ± 0.1 | 37.7 ± 0.1 | 37.5 ± 0.1 | 37.4 ± 0.1 | 37.3 ± 0.1 |
| pH | 7.51 ± 0.1 | 7.51 ± 0.0 | 7.46 ± 0.0 | 7.48 ± 0.0 | 7.46 ± 0.0 | 7.52 ± 0.0 | 7.5 ± 0.1 | 7.6 ± 0.1 |
| pO2 (mmHg) | 109.7 ± 4.4 | 114.0 ± 4.3 | 106.0 ± 4.8 | 106.9 ± 2.7 | 109.3 ± 3.4 | 114.6 ± 4.0 | 108.1 ± 4.9 | 105.0 ± 4.3 |
| pCO2 (mmHg) | 39.8 ± 0.3 | 39.8 ± 0.8 | 39.6 ± 0.6 | 39.0 ± 0.4 | 38.8 ± 0.4 | 38.5 ± 0.5 | 39.6 ± 0.7 | 39.2 ± 0.8 |
| Plasma Glucose (mg/dL) | 167.0 ± 10.6 | 164.0 ± 4.4 | 164.0 ± 4.6 | 193.3 ± 13.0 | 173.2 ± 15.8 | 155.0 ± 5.1 | 185.7 ± 6.9 | 197.3 ± 12.5 |
| Hematocrit (%) | 45.2 ± 0.6 | 46.3 ± 0.1 | 44.3 ± 0.8 | 45.6 ± 0.3 | 57.2 ± 11.7 | 46.0 ± 0.6 | 44.7 ± 0.8 | 46.7 ± 1.0 |
| After treatment (15 min) | ||||||||
| Cranial Temprature (°C) | 37.4 ± 0.1 | 37.1 ± 0.1 | 37.2 ± 0.2 | 37.1 ± 0.2 | 37.2 ± 0.2 | 37.0 ± 0.2 | 36.7 ± 0.2 | 36.9 ± 0.2 |
| Rectal Temperature (°C) | 37.7 ± 0.1 | 37.4 ± 0.2 | 37.8 ± 0.2 | 37.9 ± 0.2 | 37.7 ± 0.2 | 37.5 ± 0.1 | 36.9 ± 0.2 | 37.4 ± 0.2 |
| After treatment (24 h) | ||||||||
| Rectal Temperature (°C) | 38.2 ± 0.3 | 37.9 ± 0.3 | 37.4 ± 0.9 | 38.0 ± 0.2 | 37.8 ± 0.3 | 38.1 ± 0.4 | ||
| Body Weight (g) | 264.2 ± 5 | 268.3 ± 6.3 | 302.1 ± 6.9 | 275.5 ± 21.9 | 299.4 ± 17.0 | 287.5 ± 19.5 | ||
| After treatment (48 h) | ||||||||
| Rectal Temperature (°C) | 37.3 ± 0.1 | 36.9 ± 0.3 | 37.6 ± 0.2 | 37.5 ± 0.2 | ||||
| Body Weight (g) | 287.4 ± 8.3 | 266.8 ± 21.8 | 288.3 ± 15.4 | 279.7 ± 23.4 | ||||
| After treatment (72 h) | ||||||||
| Rectal Temperature (°C) | 37.0 ± 0.2 | 36.6 ± 0.4 | 36.2 ± 0.8 | 36.9 ± 0.5 | ||||
| Body Weight (g) | 274.3 ± 10.5 | 258.8 ± 21.6 | 281.3 ± 15.8 | 277.5 ± 26.6 | ||||