Table 2.
Incidence of progression to significant fibrosis [defined as aspartate aminotransferase to platelet ratio index (APRI) ≥ 1.5] according to level of HIV RNA replication
| n (%) | Denominator | Person-years | Rate per 100/person-years (95% CI) | |
|---|---|---|---|---|
| Overall | 57 (20) | 288 | 456.5 | 12.4 (9.2, 15.7) |
| No virological blip or rebound ever | 42 (19) | 216 | 303.8 | 13.8 (9.6, 18.0) |
| Virological blip only | 3 (11) | 28 | 45.8 | 6.6 (−0.9, 14.0) |
| Any virological rebound | 12 (27) | 44 | 69.4 | 17.3 (7.5, 27.1) |
| Number of follow-up visits with detectable HIV RNA | ||||
| 0 | 38 (18) | 209 | 304.2 | 12.5 (10.5, 14.4) |
| 1 | 8 (19) | 42 | 82.2 | 9.7 (3.0, 16.5) |
| 2–3 | 5 (25) | 20 | 36.2 | 13.8 (1.7, 25.9) |
| > 3 | 1 (17) | 6 | 18.3 | 5.5 (−5.3, 16.2) |
| Cumulative log copies of HIV RNA up to last visit | ||||
| < 2 | 39 (17) | 224 | 330.7 | 11.8 (8.1, 15.5) |
| 2–4 | 4 (20) | 20 | 43.3 | 9.2 (0.2, 18.3) |
| > 4 | 9 (27) | 33 | 66.9 | 13.4 (4.7, 22.2) |
CI, confidence interval.