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. Author manuscript; available in PMC: 2016 Jan 29.
Published in final edited form as: Cell. 2015 Jan 15;160(3):393–406. doi: 10.1016/j.cell.2014.12.018

Figure 5. SLC6a8 modulates CKB-mediated colon cancer metastasis through modulation of intracellular phosphocreatine levels.

Figure 5

A, Relative intracellular phosphocreatine and ATP levels in LvM3b cells expressing a control shRNA or shRNA targeting SLC6a8 (n=4). B, Liver metastasis by 5 × 105 LvM3b cells expressing two independent short hairpins targeting SLC6a8 (n=5). C, Liver metastasis by SW480 cells over-expressing CKB with and without SLC6a8 depletion (n>4). D, In vitro survival of LvM3b cells depleted of CKB, SLC6a8 with and without phosphocreatine supplementation in hypoxia (n=3). Error bars, s.e.m; all P values are based on one-sided Student’s t-tests, or where appropriate, Mann-Whitney test for non-Gaussian distribution. *p<0.05; **p<0.001; ***p<0.0001. See also Figure S5.