Table 2.

Cox Proportional Hazards Analysis of Plasma TMAO Levels Stratified at quartile Levels in Predicting Risk of All-cause Mortality at 5 Years Stratified by CKD and Non-CKD Cohorts

CKD Cohort (n=521)	TMAO (range)
	Quartile 1	Quartile 2	Quartile 3	Quartile 4
Range (μM)	<5.2	5.2–7.9	7.9–12.4	≥12.4
Events	26/129 (20.2%)	42/131 (32.1%)	43/130 (33.1%)	63/131 (48.1%)
Unadjusted HR	1	1.70 (1.04–2.79)*	1.75 (1.07–2.87)*	2.76 (1.74–4.37)**
Adjusted HR	1	1.42 (0.85–2.35)	1.51 (0.90–2.51)	1.93 (1.13–3.29)*

Non-CKD Cohort (n=3,166)	TMAO (range)
	Quartile 1	Quartile 2	Quartile 3	Quartile 4
Range (mM)	<2.3	2.3–3.4	3.4–5.3	≥5.3
Events	48/787 (6.1%)	59/793 (7.4%)	81/791 (10.2%)	104/795 (13.1%)
Unadjusted HR	1	1.22 (0.83–1.79)	1.70 (1.19–2.43)**	2.21 (1.57–3.12)**
Adjusted HR	1	1.08 (0.74–1.58)	1.23 (0.84–1.78)	1.47 (1.02–2.12)*

Adjusted model: adjusted for traditional risk factors (age, gender, systolic blood pressure, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, smoking, diabetes mellitus), log(hsCRP), and log(eGFR).

^*p<0.05;

^**p<0.001