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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Mol Cancer Res. 2014 Aug 28;13(1):78–85. doi: 10.1158/1541-7786.MCR-14-0334

Figure 7.

Figure 7

Collagen type IVα2 is critical to ovarian cancer cell survival. (A) Reduction in Col4α2 expression induces cell death. IGROV-1 cells transfected with Col4α2 siRNA have significantly more cell death and fewer total cells compared with their control counterparts (p < 0.005). (B) Type IV collagen is sufficient to rescue siCol4α2 cells from cell death (p < 0.01). (C) siCol4α2 show a reduction in phosphorylated Akt and Erk 1/2 as well as an increase in Bim. Shown are representative samples of 3 biological replicates. (D) siCol4α2 cells plated on exogenous collagen type IV have significantly fewer dead cells and more total cells than siCol4α2 cells plated in control wells (p < 0.01).