Figure 3. Cellular uptake and intracellular location of Tf-NP-siRNA in MV4–11 cells.
(A) Flow cytometry analysis on expression levels of TfR (also known as CD71) on the surface of AML cells. Cells were surface stained with PE-labeled anti-TfR (anti-CD71) monoclonal antibodies (BD Biosciences, San Jose, CA) for 30min on ice, followed by flow cytometry analysis. (B) Cellular uptake of FAM-labeled Tf-NP-siRNA by flow cytometry. (C) Intracellular localization of Tf-NP-siRNA 4 h after transfection by confocal microscopy.