. Author manuscript; available in PMC: 2015 Aug 21.

Published in final edited form as: Nanoscale. 2014 Jul 8;6(16):9742–9751. doi: 10.1039/c4nr01510j

Table 1.

Pharmacokinetic parameters of Tf–NP–Cy3–siRNA and free Cy3–siRNA after i.v. bolus administration at 1 mg per kg bw

Parameters	Unit	Free siRNA	Tf–NP–siRNA
C_max	µg ml⁻¹	2.27	2.72
t_1/2α	h	0.06	0.18
t_1/2β	h	2.93	10.2
Vss	ml kg⁻¹	2.38	2.37
CL	ml kg⁻¹ h	0.63	0.18
AUC	h µg ml⁻¹	1.58	5.46
MRT	h	3.78	12.96