Table 2.
Concentrations (mM) of AgNPs distributes in various locations of rat ear after transtympanic injection measured by μCT
| AgNP con delivered | Time | ME | ME-flu | Mall | Inc | Stap | StapArt | StapFoot | OW | RWM | Coc | EEC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 371 | 5 h | 1270 | 547 | 677 | 500 | 769 | 1038 | 639 | 1177 | |||
| 371 | 4 h | 1084 | 232 | 269 | 408 | 677 | 232 | |||||
| 371 | 24 h | 816 | 639 | 769 | 639 | 1177 | ||||||
| 371 | 24 h | 677 | 593 | 723 | 1084 | 769 | 955 | 1177 | 593 | |||
| 37 | 4 h | 139 | ||||||||||
| 37 | 1 w | 232 | 93 | |||||||||
| 37 | 1 w | 185 |
Intensities in various locations of rat ear after transtympanic injection of AgNPs were normalized by the intensities of the cochlear perilymph imaged by μCT. The concentrations of AgNPs were estimated using the formula of y = 4.88x-4.86 obtained in a phantom study, where “y” is the concentration and “x” is the normalized intensity. AgNP con: AgNP concentration; Coc: cochlea; EEC: external ear canal; Inc: incus; ME: middle ear mocusa; ME-flu: middle ear fluid; Mall: malleus; OW: oval window; RWM: round window membrane; Stap: stapes; StapArt: stapedial artery.