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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Exerc Sport Sci Rev. 2004 Oct;32(4):161–166. doi: 10.1097/00003677-200410000-00007

Figure 3.

Figure 3

Skeletal muscle LPL mass and activity in response to physical inactivity. Measurement of the temporal changes in LPL mRNA, protein mass, and activity in both the capillary pool and total tissue at the onset and throughout a day of physical inactivity gives insight into the underlying mechanisms triggering the changes in LPL activity. After an initial lag period of approximately 4 h, there is a precipitous loss of capillary LPL protein that is closely paralleled by a simultaneous decrease in capillary LPL activity (measured in both soleus and red quadriceps muscles at many time points) (2). Coincident with the early events, there is likely a decrease in intracellular-specific LPL activity because total tissue LPL protein does not change initially, yet total tissue LPL activity decreases. Eventually, total LPL protein decreases. Importantly, the loss of LPL activity during physical inactivity does not require a decrease in LPL mRNA concentration (Fig. 4).