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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Exerc Sport Sci Rev. 2004 Oct;32(4):161–166. doi: 10.1097/00003677-200410000-00007

Figure 5.

Figure 5

Potential steps involved in decreasing LPL during contractile inactivity. The decrease in muscle LPL does not occur because of less LPL mRNA concentration (Figure 2). The pharmacologic inhibition of transcription prevented the decrease in LPL activity in sedentary muscle, but did not affect LPL activity in muscle of ambulatory and exercising rats (2). There is also potentially a reduction in intracellular LPL specific activity that may be involved. Conversely, the decrease in intracellular LPL mass may be a consequence of a process that causes a rapid loss of LPL mass at the capillary endothelium. Light or intense muscle contractions can prevent the upregulation or activation of a gene(s) that suppresses capillary LPL mass and activity (as described in text) (2). Loss of capillary LPL activity can reduce plasma triglyceride uptake and plasma HDL cholesterol concentration in some conditions and likely has other ensuing effects on lipid and carbohydrate metabolism.