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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Neuropharmacology. 2014 Dec 4;0:57–62. doi: 10.1016/j.neuropharm.2014.11.026

Figure 2. SAG-induced depression is dependent on Ca2+.

Figure 2

(a) SAG-induced depression at −50 mV was blocked by simultaneous loading of BAPTA (SAG+BAPTA) A 2-way repeated measures ANOVA revealed significant interaction and a significant difference between SAG alone and SAG+BAPTA. Individual SAG and SAG+BAPTA time points were compared using Sidak’s post-hoc analysis; ** p<0.01, ***p<0.001, ***p<0.0001). Neither BAPTA+SAG (113±15% baseline) nor BAPTA alone (94±9% baseline) showed a significant change from baseline (P>0.05 by one-sample ttest) and were not significantly different from each other (p>0.05 by 2-way repeated measures ANOVA). Representative traces for each condition (1: black trace, 2: gray line) are shown to the right (scale bars 100 pA, 10 ms). (b) The SAG-induced increase in PPR was also blocked by co-loading BAPTA (p>0.05 by paired t-test).