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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Mol Genet Metab. 2014 Dec 9;114(2):94–109. doi: 10.1016/j.ymgme.2014.12.001

Figure 2.

Figure 2

Age-dependent change of storage vacuoles at an early stage in cartilage of MPS VII mouse model. Left panel: 2-3 days old, middle panel: 2.5 weeks old, right panel: 5 weeks old. Clear vacuoles are observed in most chondrocytes at birth. Vacuoles in chondrocytes increase in number with age and storage materials are fully accumulated at the age of 5 weeks old. Vacuolization and disorganization of the column structure in articular cartilage is more progressive than seen in epiphyseal cartilage (toluidine blue-stained 0.5-μm-thick sections: X 40).