Table 5.

Unadjusted association of brain volume with neurocognitive scores among MPS II subjects.

Score	Volume	Difference in Score (95% CI)	P-value
Errors of omission	Corpus callosum (per mL)	11.83 (−5.52, 29.17)	0.181
Errors of commission	Corpus callosum (per mL)	4.14 (−10.03, 18.30)	0.567
Reaction time	Corpus callosum (per mL)	13.53 (4.59, 22.47)	0.003
Variability	Corpus callosum (per mL)	21.43 (8.04, 34.81)	0.002
PSS (total)	Corpus callosum (per mL)	1.32 (−0.05, 2.70)	0.060
SOC: Problems solved	Corpus callosum (per mL)	0.72 (−0.23, 1.66)	0.137
SWM: Errors	Corpus callosum (per mL)	0.12 (−0.77, 1.02)	0.785

Score	Volume	Difference in Score (95% CI)	P-value
Errors of omission	Cortical white matter (per mL)	0.08 (−0.10, 0.26)	0.402
Errors of commission	Cortical white matter (per mL)	0.08 (−0.05, 0.20)	0.221
Reaction time	Cortical white matter (per mL)	0.17 (0.00, 0.34)	0.052
Variability	Cortical white matter (per mL)	0.26 (0.10, 0.41)	0.001
PSS (total)	Cortical white matter (per mL)	0.01 (0.00, 0.03)	0.148
SOC: Problems solved	Cortical white matter (per mL)	0.01 (0.00, 0.02)	0.024
SWM: Errors	Cortical white matter (per mL)	0.00 (−0.01, 0.01)	0.464

Score	Volume	Difference in Score (95% CI)	P-value
Errors of omission	Total frontal lobe (per mL)	0.10 (−0.22, 0.41)	0.545
Errors of commission	Total frontal lobe (per mL)	−0.14 (−0.39, 0.12)	0.294
Reaction time	Total frontal lobe (per mL)	0.14 (−0.18, 0.46)	0.376
Variability	Total frontal lobe (per mL)	0.05 (−0.48, 0.57)	0.858
PSS (total)	Total frontal lobe (per mL)	−0.02 (−0.04, 0.01)	0.179
SOC: Problems solved	Total frontal lobe (per mL)	0.04 (0.01, 0.06)	0.007
SWM: Errors	Total frontal lobe (per mL)	0.02 (−0.01, 0.05)	0.230

Score	Volume	Difference in Score (95% CI)	P-value
IQ	Cortical gray matter (per mL)	0.07 (0.00, 0.15)	0.055