Table 1.

Table showing list of existing PLD inhibitors, their abbreviations, chemical structure and isoform specificity. Also mentioned are the IC₅₀ values.

PHOSPHOLIPASE D (PLD) INHIBITORS
IUPAC name	Abbrev. name (this paper)	Chemical structure	Isoform specificity
N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,-8-triazaspiro[4,5]dec-8-yl]ethyl]-2-naphthalenecarboxamide. (Lavieri RR et al, J Med Chem, 2010)	NFOT		PLD2 inhibitor
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide. (Lewis JA et al, Bioorg Med Chem Lett, 2009)	NOPT		PLD2 inhibitor
N-[2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-naphthalenecarboxamide. (Lewis JA et al, Bioorg Med Chem Lett, 2009)	NBOD		PLD1 inhibitor
(1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide. (Lewis JA et al, Bioorg Med Chem Lett, 2009)	RBPC		PLD1 inhibitor
N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide Other name: 5-Fluoro-2-Indolyl des-Chlorohalopemide. (Su W et al, Mol Pharmacol, 2009)	FIPI		Dual (PLD1 and PLD2) inhibitor