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Histone variants during preimplantation development. (A) Schematic representation of nucleosome structure and histone variants. (B) Changes in histone variant deposition during preimplantation development. Notably, there are significant contributions of H2A.X and H3.3 to totipotent 1C and 2C chromatin, which links the presence of these histones to totipotency. Abbreviation: CENP-A, centromeric histone 3.
