Table IV.

Correction of behavioral abnormalities in MPS IIIA mice

Test/parameter	Improvementa
	Vector/route of delivery
	AAV8 [96] i.v.	LV-HSC [120] i.v.	AAV2/8 [119] i.v.	AAV9 [79] intrathecalb
Accelerated rotarod
1) latency to fall	–	n/d	n/d	n/d
Open-filed tests
1) total distance travelled	n/d	+	+	+
2) number of lines crossed	n/d	n/d	n/d	+
3) number of rearings	n/d	n/d	n/d	+
4) frequency, duration of motion	n/d	+	+	n/d
5) time spent in central area	n/d	+	+	n/d
6) frequency of center entries	n/d	+	+	n/d

^aImprovement: +, significant; –, no correction; i.v., intravenous; n/d, not determined

^bhigh-dose AAV9@5×10¹⁰VG/mouse