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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Trends Cell Biol. 2014 Nov 7;25(2):65–73. doi: 10.1016/j.tcb.2014.10.002

Figure 4. Improper anchoring of astral microtubules at cell cortex as a source of spindle geometry defects.

Figure 4

In cells with normal spindle geometry (left), dynein/dynactin interacts with the Gαi-LGN-NuMA anchor protein complex [89] and captures astral microtubules near the cortex contributing to symmetrical spindle pole orientation and proper kinetochore-microtubule attachment. In cells with abnormal spindle geometry, demarcation of cortical anchoring regions is not symmetrical, resulting in improper kinetochore-microtubule attachment (right).