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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Free Radic Biol Med. 2014 Aug 1;0:171–182. doi: 10.1016/j.freeradbiomed.2014.07.037

Figure 1. Mechanistic aspects of thiol-disulfide exchange reactions.

Figure 1

Panel I illustrates reduction of a CxxC disulfide motif in Aox by an unstructured reduced peptide dithiol (Bred; blue). Generation of the mixed-disulfide intermediate A-B involves an in-line transition state as depicted in the detail shown in Panel II.