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PDI-second pathways of oxidative folding. The initial oxidation of reduced proteins is PDI-independent so that PDI is only engaged in the second phase of oxidative protein folding (Panel A). One facile direct oxidant of reduced conformationally-mobile proteins is Quiescin-sulfhydryl oxidase. Panel B shows the structure of the open form of QSOX from Trypanosoma brucei (3QCP; [52]).
