Table 2.

Determination of the redox state of PDIs within the ER. In a number of references the redox state of PDI family members was not quantified densitometrically. In most cases the overall redox state of PDI family members that carry multiple CxxC motifs is reported in aggregate, without identification of the population of redox isoforms (but see entry 4; here, the percentage of CxxC domains that are reduced totals 67%).

Entry	Biological Sample	Method	Protein	Redox State	Year/Reference
1	Hela, COS, U937 cells	TCA/intact cells	PDI and ERp57	Predominantly Reduced	2001/ [93]
2	HT1080 cells	NEM soaking/intact cells	PDI, ERp57, ERp72, P5, PDIr	Predominantly Reduced	2004/ [53]
3	Rat Liver Microsomes	Microsome Isolation /TCA	PDI and ERp57	Predominantly Oxidized	2005/[78]
4	HEK-293 cells	NEM soaking/ intact cells	PDI TMX3	50% fully reduced, 18% a-oxidized, 15% a′-oxidized, and 16% fully oxidized Predominantly Reduced	2008/[94]
5	Rat Heart Tissue	Tissue frozen in liquid nitrogen	PDI	Predominantly Reduced	2011/ [95]
6	HeLa cells	NEM soaking/intact cells	ERp57	Predominantly Reduced	2013/[73]
7	HEK293	TCA treatment intact cells	PDI, ERp46, ERp57, P5, ERp72	Predominately Reduced 0%-20%	2013/[77]