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. Author manuscript; available in PMC: 2016 Feb 11.
Published in final edited form as: Vaccine. 2015 Jan 3;33(7):869–878. doi: 10.1016/j.vaccine.2014.12.056

Fig. 7.

Fig. 7

TLR7 and RIG-I are responsible for higher IFN and proinflammatory cytokine production in WNV NS4B-P38G –infected THP-1 cells. Cells were transfected with siRNAs to TLR7 (A-B, siTLR7), or siRNA to RIG-I (C, siRIG-I) as described in Materials & Methods. Cells treated with the same concentration of scrambled siRNA were used as controls. Cells were harvested from mock and WNV NS4B-P38G-infected cells at day 1 post infection. The fold increase compared to that of the mock-infected group was shown. Data are presented as means ± SEM, n = 4. * P < 0.05 or **P < 0.01 compared to control vector-treated cells.