TABLE 3.
Drakenstein Infant Lung Function Compared European Birth Cohort
| Drakenstein pilot study (N = 20) | European study (N = 296)18 | |||
|---|---|---|---|---|
| Mean (SD) | Median (IQR) intra-subject CV1 | Mean (SD) | Median (IQR) intra-subject CV1 | |
| Tidal breathing N successful test (%) | 19 (95) | 285 (96) | ||
| Tidal volume (ml) mean (SD) | 30.5 (5.8) | 6.8 (6; 7.9) | 32.4 (5.5) | 8.6 (7.1; 10.8) |
| Respiratory rate breaths per min, mean (SD) | 49.4 (8.4) | 7.7 (6.5; 9.3) | 45.2 (10.5) | 9.1 (7.4; 11.3) |
| Minute ventilation (ml/min), mean (SD) | 1,487.4 (319.8) | 6.5 (4.6; 8.3) | 1,420 (277) | 7.5 (6.1; 10.1) |
| PTEF/TE2 | 37 (11.5) | 19.7 (15.6; 25.2) | 34.8 (10.7) | 23.8 (20.2; 28.4) |
| Multiple breath washout N successful tests (%) | 18 (90) | 201 (68) | ||
| FRC3 (ml), mean (SD) | 70.7 (13) | 6.8 (4.5; 8.8) | 102 (16) | 6.3 (4.4; 8.3) |
| LCI4 | 7.6 (0.5) | 3.6 (1.6; 6.4) | 6.75 (0.6) | 5.8 (3.6; 8.0) |
| Exhaled nitric oxide N successful tests (%) | 19 (95) | 261 (88) | ||
| NO5 ppb | 10.4 (7.3) | 4.2 (3.3; 5.5) | 14.3 (6) | 10.3 (6.4; 15.7) |
| NO output (mcl/sec) | 7.8 (2.2) | 2.3 (0.8; 3) | 6.3 (2.5) | 12.4 (8.9–18.1) |
1
Coefficient of variation.
2
Ratio of time to peak tidal expiratory flow over total expiratory time.
3
Functional residual capacity.
4
Lung clearance index.
5
Nitric oxide.