Table 2. Activation differences between BD patients, relatives and their respective controls and PPI results.
| H | BA |
MNI coordinates |
Cs | Z-value | T-value | |||
|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||
| Rel>Con: reappraisal–view emotional | ||||||||
| Amygdala | L | −21 | −7 | −14 | 20 | 3.06 | 3.32 | |
| R | 33 | 5 | −20 | 26 | 2.87 | 3.09 | ||
| Ventral ACC | L | 10 | −12 | 50 | −2 | 108 | 4.20 | 4.90 |
| Insula | L | 48 | −39 | 2 | −11 | 69 | 3.36 | 3.71 |
| R | 48 | 36 | −16 | 1 | 161 | 3.84 | 4.37 | |
| BD>Con: reappraisal–view emotional | ||||||||
| Amygdala | L | −15 | −4 | −17 | 18 | 2.99 | 3.18 | |
| Amygdala/parahippocampal | R | 21 | 5 | −26 | 60 | 4.31 | 4.87 | |
| BD>Con: PPI L-amygdala seed | ||||||||
| Orbitofrontal | L | 47 | −42 | 35 | −8 | 53 | 4.94 | 5.79 |
| BD>Con: PPI R-amygdala seed | ||||||||
| Orbitofrontal | L | 47 | −12 | 50 | −5 | 23 | 4.41 | 5.01 |
| Rel>Con: PPI L-amygdala seed | ||||||||
| Orbitofrontal | L | 47 | −39 | 29 | −14 | 60 | 4.45 | 5.29 |
| R | 47 | 36 | 56 | −8 | 15 | 4.59 | 5.52 | |
| Rel>Con: PPI R-amygdala seed | ||||||||
| Orbitofrontal | R | 47 | 39 | 56 | −5 | 49 | 5.06 | 6.33 |
Abbreviations: BA, Brodmann area of the peak activation; Con, control; CS, cluster size in number of activated voxels; H, hemisphere; L, left; MNI, Montreal Neurological Institute; PPI, psychophysiological interaction analysis; R, right; Rel, relative.