Fig. 1.

Assessment of systemic hemodynamics and locomotor activity in the same mice under naive and septic conditions. Mean arterial pressure (MAP; A), heart rate (B), and locomotor activity (C), before and after induction of sepsis [at time 0: lipopolysaccharide (LPS), 12.5 mg/kg, or cecal ligation and puncture (CLP)] or sham procedures are shown. Boxed regions denote periods of darkness. Data were acquired by radiotelemetry in conscious, ambulatory male C57BL/6 mice and are presented as means ± SE; n = 6–11. bpm, Beats/min.