Table 2.

Cardiac function before and after induction of sepsis

	Sham	6-h CLP	24-h CLP	Naive	6-h LPS	24-h LPS
Cardiac output, ml/min	27.2 ± 1.5	19.7 ± 1.5†	18.3 ± 1.6‡	32.9 ± 1.4	22.0 ± 1.9‡	22.0 ± 1.1‡
Stroke volume, μl	49.6 ± 2.5	38.8 ± 3.7*	26.7 ± 3.9*	60.0 ± 2.5	44.9 ± 4.9*	43.7 ± 1.3*
End-diastolic left ventricular volume, μl	78.8 ± 5.2	59.1 ± 5.8	48.8 ± 6.2†	94.3 ± 3.6	116.1 ± 9.1	77.7 ± 9.4
Ejection fraction, %	63.8 ± 2.4	66.2 ± 2.7	77.4 ± 3.3*	63.4 ± 2.4	39.5 ± 2.0‡	57.1 ± 6.4
Fractional shortening, %	34.6 ± 1.8	36.2 ± 2.1	46.4 ± 3.5†	34.5 ± 1.8	19.3 ± 1.1†	30.6 ± 4.3
Aortic flow, mm/s	1438 ± 82	1337 ± 98	1152 ± 63	1519 ± 56	808 ± 36‡	1136 ± 97*

Values are means ± SE, n = 6–8 mice. Cardiac function was recorded by echocardiography (Vevo 770) in homeothermically heated (to 36°C), unconscious (1.8% isofluorane) naive and sham-operated animals, and 6 and 24 h post-LPS and post-CLP.

^*P < 0.05,

^†P < 0.01,

^‡P < 0.001 relative to sham/naive, one-way ANOVA + Bonferroni post hoc test.