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Mean arterial blood pressures during increasing doses of nicotine (ia). (−)Nicotine (ia; ○, solid line; n = 5), as well as stereoisomer (+)nicotine (ia; △, dotted and dashed line; n = 5), significantly reduced blood pressure at doses of 10 μg/kg and higher. Mecamylamine (24 μg/kg) injected in vertebral artery (■, dotted line; n = 5) prevented the depressor effect of nicotine. Values are means ± SE.
