Table 1.
The timing and magnitude of syllable-locked firing patterns across putatively identified cell classes during vocal babbling
| GPi | MSN | GPe | FS | TAN | LTS | |
|---|---|---|---|---|---|---|
| Dominant rate change, syllable onset, Hz | 18.9 ± 6.1 | 4.3 ± 1.7 | −19.8 ± 7.4 | 15.9 ± 14.0 | 20.0 ± 8.2 | N/S |
| Peak of dominant rate change, syllable onset, ms | −16 ± 32 | −9 ± 32 | −18 ± 30 | −8 ± 10 | −15 ± 13 | N/S |
| Onset of dominant rate change, syllable onset, ms | −45 ± 20 | −3 ± 60 | −37 ± 30 | −27 ± 17 | −43 ± 13 | N/S |
| Width of dominant rate change, onset, ms | 41 ± 20 | 30 ± 13*† | 47 ± 11 | 38 ± 13 | 53 ± 14 | N/S |
| No. cells with dominant rate increase at onset | 22/26 | 15/20 | 0/15 | 4/5 | 11/13 | 0/10 |
| No. cells with dominant rate decrease at onset | 0/26 | N/A | 12/15 | N/A | 0/13 | 0/10 |
| Onset reliability, %syllable onsets exhibiting dominant rate change | 60 ± 6 | N/A | 59 ± 5 | N/A | 67 ± 7*‡ | N/S |
| Dominant rate change, syllable offset, Hz | −13.7 ± 6.6 | N/A | 15.0 ± 5.0 | N/A | −17.2 ± 12.7 | N/S |
| Peak of dominant rate change, syllable offset, ms | −29 ± 42 | N/A | −1 ± 60 | N/A | −17 ± 16 | N/S |
| Onset of dominant rate change, syllable offset, ms | −43 ± 46 | N/A | −27 ± 67 | N/A | −43 ± 13 | N/S |
| Width of dominant rate change, offset, ms | 37 ± 14 | N/A | 38 ± 16 | N/A | −53 ± 13 | N/S |
| No. cells with dominant rate increase at offset | 40/26 | 0/20 | 6/15 | 0/5 | 0/13 | 0/10 |
| No. cells with dominant rate decrease at offset | 14/26 | N/A | 0/15 | N/A | 7/13 | 0/10 |
| Offset reliability, %syllable offsets exhibiting dominant rate change | 55 ± 15 | N/A | 55 ± 17 | N/A | 56 ± 3 | N/S |
Values are means ± SD across cells within a cell class.
GPi, globus pallidus internal segment; MSN, medium spiny neurons; GPe, globus pallidus external segment; FS, fast spiking; TAN, tonically active; LTS, low-threshold spiking; N/A, not applicable.
For each cell class, the magnitude of the dominant maximal rate change (Hz), its timing relative to syllable onset and offset, its reliability across syllables, and the number of cells with statistically significant dominant rate increases and decreases in syllable onset- and offset-aligned histograms are shown (see materials and methods). Note that these data were acquired from syllable-locked rate histograms that exhibited statistically significant rate changes. N/S indicates that there were no such histograms in that cell class dataset. Note also that rate decreases in rate histograms on onset/offset reliability were not computed in MSN and FS cell classes due to their sparse firing. A different metric, the percentage of syllables with a spike, is shown in Table 3. See materials and methods for analysis details.
P < 0.05 in unpaired t-test compared with the cell classes indicated.
<GPe and TAN.
>GPi and GPe.