Fig 3.

Regulatory network governing early B-cell development. Key factors involved in lineage priming are depicted on the left while major transcription factors regulating B-cell specification and commitment are shown in the orange box. Genes promoting alternative lineage decisions are highlighted in gray (innate lymphoid lineage), light green (myeloid lineage), and light purple (T-cell lineage). Positive regulation is depicted with thick lines that end in an arrow, while repression is represented by thin, barred lines.