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. 2014 Nov 19;308(3):H157–H182. doi: 10.1152/ajpheart.00457.2014

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Fig. 1. — A phylogenetic tree of human, Zebrafish, and Drosophila transient receptor potential (TRP) channels. Sequence homology analyses show that all TRP channels fall into 7 subfamilies that comprise proteins with distinct channel properties. Because human TRPC2 is a pseudogene, mTRPC2 (mouse) is used for analysis. Aligned by ClustalW, the phylegenic tree was generated according to Jukes-Cantor Genetic Distance Model, and the tree was built by the Neighbor-Joining method. All calculation was done in Geneious software. h, homo sapiens; dr, Danio rerio; dm, Drosophila melanogaster. The TRP subfamilies are represented by different colors. Gene accession numbers are shown as follows: 1) Human TRP channels: canonical TRP (TRPC): hTRPC1 (EAW78963), hTRPC3 (NP_001124170), hTRPC4 (AAI04726), hTRPC5 (EAX02630), hTRPC6 (AAH93660), hTRPC7 (AAI28186); mTRPC2 (NP_001103367); vanilloid TRP (TRPV): hTRPV1 (NP_542437), hTRPV2 (NP_057197), hTRPV3 (NP_001245134), hTRPV4 (NP_067638), hTRPV5 (NP_062815), hTRPV6 (NP_061116); melastatin TRP (TRPM): hTRPM1 (NP_001238949), hTRPM2 (NP_003298), hTRPM3 (Q9HCF6), hTRPM4 (NP_060106), hTRPM5 (NP_055370), hTRPM6 (NP_060132), hTRPM7 (NP_060142), hTRPM8 (NP_076985); polycystic (TRPP): hTRPP2 (NP_000288), hTRPP3 (NP_057196), hTRPP5 (NP_055201); hTRPML1 (NP_065394), hTRPML2 (NP_694991), hTRPML3 (NP_060768); ankyrin TRP (TRPA): hTRPA1(NP_015628). 2) Zebrafish TRP channels: TRPC: drTRPC1 (AGW27444), drTRPC2a (AGW27445), drTRPC3 (AGW27447), drTRPC4a (AGW27448), drTRPC5a (AGW27450), drTRPC6a (AGW27452), drTRPC7a (AGW27454); TRPV: drTRPV1 (NP_001119871), drTRPV4 (NP_001036195), drTRPV6 (NP_001001849); TRPM: drTRPM1a (AGS55979), drTRPM2 (AGS55981), drTRPM3 (AGS55982), drTRPM4a (AGS55983), drTRPM5 (AGS55987), drTRPM6 (AGS55988), drTRPM7 (AGS55989); mucolipin TRP (TRPML): drTRPML1 (AAH54127), drTRPML2 (NP_957442); TRPA: drTRPA1 (NP_001007066); TRPP: drPKD2 (NP_001002310); TRPN: drTRPN (NP_899192). 3) Drosophila TRP channels (74): TRPC: dmTRP (NP_476768), dmTRPL (AAF58904), dmTRP γ (AAF53548); TRPV: dmTRPV_(NANCHUNG) (AAF49752), dmTRPV_(CG4536) (AAF46203); TRPM: dmTRPM (a) (NP_001137672); TRPML: dmTRPML (NP_649145); TRPN: dmTRPN (AAF52248); TRPA: dmTRPA1 (NP_476768), dm pain (AAF47293), dmwtrw (AHN57213), dmpyx (AAF47356); TRPP: dmTRPP1 (NP_609561).