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Effect of deafferentation or cyclooxygenase (COX) inhibition on acetate-induced HCO3− secretion in vivo. The duodenal loop was perfused with acetate (0.1 mM) under capsaicin (Cap)-treated (A) or indomethacin (IND)-treated (B) conditions. Cap or IND treatment significantly decreased the acetate-induced HCO3− secretion; n = 6. *P < 0.05 vs. the pH 7.0 Krebs group. *†P < 0.05 vs. the acetate group.
