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Activation of Gα12 led to cell morphology change and shedding of E-cadherin (E-cad). A: Gα12WT and Gα12QL (constitutively active) were induced by removal of doxycycline (Dox) for 48 h in MDCK cells. Typical phase contrast images are shown here. B: the expression of Gα12 increased the shedding of E-cadherin. C: knockdown of PC1 increased the shedding of E-cadherin. D: in renal cystic fluid of ADPKD mice, the shed fragment of E-cadherin was increased.
