TABLE 1.
MIC distributions of anidulafungin and caspofungin versus Candida spp., including strains with fks mutations, using reference CLSI methods
| Species (no. tested) | Antifungal agent | No. of isolates (no. with fks mutation) at indicated MIC (μg/ml) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.008 | 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | ≥8 | ||
| C. albicans (2,307) | Anidulafungin | 121 | 574 | 866 | 547 (1) | 174 (2) | 13 (1) | 2 (1) | 4 (3) | 6 | ||
| Caspofungin | 38 | 625 | 1,054 | 538 | 23 | 12 (2) | 11(2) | 3 (2) | 2 (2) | 1 | ||
| C. glabrata (655) | Anidulafungin | 1 | 72 (1) | 282 (6) | 228 (4) | 30 (6) | 4 (3) | 21 (20) | 9 (8) | 8 (7) | ||
| Caspofungin | 37 | 334 (1) | 210 (6) | 20 (3) | 10 (6) | 13 (10) | 7 (6) | 8 (8) | 2 (2) | 14 (13) | ||
| C. parapsilosis (539) | Anidulafungin | 1 | 1 | 7 | 14 | 110 | 364 | 42 | ||||
| Caspofungin | 1 | 1 | 1 | 17 | 35 | 208 | 219 | 49 | 7 | 1 | ||
| C. tropicalis (515) | Anidulafungin | 9 | 110 | 270 | 92 | 21 (1) | 6 | 2 (1) | 2 (2) | 3 | ||
| Caspofungin | 5 | 164 | 239 | 93 | 5 (1) | 4 | 2 (1) | 2 (3) | 1 | |||
| C. krusei (124) | Anidulafungin | 4 | 55 | 52 | 9 | 3 (2) | 1 (1) | |||||
| Caspofungin | 1 | 1 | 53 | 38 | 21 | 6 | 3 (2) | 1 (1) | ||||
| C. guilliermondii (64) | Anidulafungin | 2 | 2 | 2 | 30 | 23 | 5 | |||||
| Caspofungin | 1 | 2 | 7 | 15 | 28 | 8 | 3 | |||||
| C. lusitaniae (57) | Anidulafungin | 7 | 21 | 28 | 1 | |||||||
| Caspofungin | 1 | 1 | 24 | 28 | 2 | 1 | ||||||
| C. kefyr (29) | Anidulafungin | 2 | 14 | 12 | 1 (1) | |||||||
| Caspofungin | 4 | 23 | 1 | 1 (1) | ||||||||