TABLE 4.
Isolates of C. albicans, C. glabrata, C. tropicalis, C. krusei, and C. kefyr harboring fks mutations
Species | Amino acid change(s) corresponding to fks mutation | MIC (μg/ml) |
|
---|---|---|---|
Anidulafungin | Caspofungin | ||
C. albicans | S629P | 1 | 2 |
F641Y | 0.25 | 1 | |
F641S | 0.12 | 0.5 | |
S645P | 1 | 2 | |
S645F | 0.5 | 0.5 | |
S645Y | 1 | 1 | |
D648Y | 0.06 | 0.25 | |
P649H | 0.12 | 0.25 | |
C. glabrata | F625Y | 0.25 | 0.12 |
F625S | 1 | 0.5 | |
F625S | 2 | 2 | |
F625S | 2 | 2 | |
S629P | 2 | 16 | |
S629P | 2 | 16 | |
S629P | 2 | 16 | |
S629P, R631S | 4 | 2 | |
L630I | 0.03 | 0.03 | |
R631G | 0.12 | 0.12 | |
D632Y | 0.25 | 0.12 | |
D632E | 1 | 0.5 | |
D632E | 1 | 1 | |
I634V | 0.06 | 0.06 | |
I634V | 0.06 | 0.06 | |
I634V | 0.06 | 0.06 | |
I634V | 0.06 | 0.06 | |
F659S | 0.5 | 0.5 | |
F659S | 0.25 | 0.25 | |
F659S | 1 | 0.5 | |
F659V | 1 | 8 | |
F659V | 1 | 2 | |
F659V | 1 | 4 | |
F659V | 1 | 2 | |
F659Y | 1 | 1 | |
F659Y | 1 | 2 | |
L662W | 2 | 1 | |
L662W | 1 | 0.5 | |
S663F | 0.5 | 0.25 | |
S663F | 0.5 | 0.25 | |
S663P | 1 | 1 | |
S663P | 4 | 16 | |
S663P | 2 | 2 | |
S663P | 4 | 4 | |
S663P | 1 | 2 | |
S663P | 4 | 16 | |
S663P | 2 | 8 | |
S663P | 0.25 | 0.5 | |
S663P | 4 | 16 | |
S663P | 1 | 8 | |
S663P | 0.25 | 0.5 | |
S663P | 4 | 16 | |
S663P | 1 | 8 | |
S663P | 1 | 1 | |
S663P | 4 | 16 | |
S663Y | 1 | 0.5 | |
L664R | 1 | 0.5 | |
R665G | 0.25 | 0.5 | |
R665S | 0.12 | 0.5 | |
D666Y | 0.12 | 0.25 | |
P667T | 1 | 1 | |
ΔF658 | 1 | 16 | |
I1379V | 0.06 | 0.06 | |
I1379V | 0.06 | 0.06 | |
P1371S | 0.12 | 0.25 | |
C. tropicalis | F641S | 1 | 1 |
F641S | 0.12 | 0.12 | |
S645P | 1 | 2 | |
S645P | 0.5 | 2 | |
C. krusei | F655C | 0.5 | 1 |
R1361G | 1 | 16 | |
L701M | 0.03 | 0.25 | |
C. kefyr | S663P | 2 | 0.5 |